How to take tramadol?

Tramadol hydrochloride must be used in combination with caution in patients to comprehend intracranial pressure or head injury. The respiratory depressant connection between opioids include fractional co2 retention and secondary elevation of cerebrospinal fluid pressure, and could be markedly exaggerated during these patients. Additionally, pupillary changes (miosis) from tramadol may obscure the existence, extent, or length of intracranial pathology. Clinicians must also keep a high index of suspicion for adverse drug reaction when looking for altered mental status in these patients if they are receiving tramadol hydrochloride (see WARNINGS, Respiratory Depression ).